Early Subclinical Cardiovascular Disease is Associated with Elevated Remnant Cholesterol and ApoB-lipoproteins in Young Women with and without Polycystic Ovary Syndrome
نویسندگان
چکیده
Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder affecting 10% of women. PCOS increases risk developing diabetes and cardiovascular disease (CVD). We have previously shown high-risk young women with without an atherogenic lipoprotein profile, this exacerbated in PCOS, elevated triglycerides (TG), remnant cholesterol apoB-lipoproteins. The aim study was to determine association profile atherosclerotic CVD (ACVD) cardiac function control PCOS. In overweight-obese (BMI >25kg/m2) aged 18-45 years healthy-weight controls a standard lipid panel, cholesterol, total apoB, apoB48 apoB100-lipoproteins were determined by calorimetry western blot. Carotid intimal-medial thickness (cIMT), presence carotid plaque ultrasound 3D-echocardiography. BMI-matched (n-45) (n=20) had 25%-60% higher TG, non-HDLC, apoB apoB48-lipoproteins compared (n=10). 40% TG controls. 3- 8-fold healthy weight controls, respectively. increased cIMT, left ventricular (LV) Mass LV longitudinal strain 10-20%. High-risk ACVD early impairment indices that associated These results suggest screening primary prevention reduce premature
منابع مشابه
Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome.
In addition to its effects on reproductive health, it is now well recognized that polycystic ovary syndrome (PCOS) is a metabolic disorder, characterized by decreased insulin sensitivity which leads to an excess lifetime risk of type 2 diabetes and cardiovascular disease. PCOS patients are often obese, hypertensive, dyslipidemic and insulin resistant; they have obstructive sleep apnea and have ...
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ژورنال
عنوان ژورنال: Canadian Journal of Cardiology
سال: 2023
ISSN: ['0828-282X', '1916-7075']
DOI: https://doi.org/10.1016/j.cjca.2023.02.041